Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC056
Sex MALE
Dominant hand LEFT
Test administered by neuromedic@manusdevices.net
Test date and time 2022-09-26 12:06
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment Madopar 250mg 1\2 1\4 1\2 1\4 Requip 2x4 madopar HBS 1x1

Overall Assessment

PD

Subject performance similar to PD population (recommend review of report details)

Clinical context

In the clinical reference population, 34 individuals with a value less than 0.68 were subsequently diagnosed with PD. That is, 80.95% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.68 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 2, 'TN': 2, 'TP': 40, 'FP': 28}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 20, 'TN': 17, 'TP': 22, 'FP': 13}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 29, 'TN': 23, 'TP': 13, 'FP': 7}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 9, 'TN': 5, 'TP': 33, 'FP': 25}

Test Battery Details

Circle

numCircles 10
timePerCircleMean 11.588
timePerCircleCoV 0.217604
timePerCircleSlope -0.0338281
meanError 1.69978
tremorFreq 6.15234
tremorRelPower 21.1119
tremorGyroAmpMean 0.0120984
tremorGyroAmpSlope -0.000608793
tremorGyroAmpCoV 0.370719
tremorCoordAmpMean 0.0313189
tremorCoordAmpSlope 0.00272705
tremorCoordAmpCoV 0.293698
tremorAccAmpMean 0.0673163
tremorAccAmpSlope 0.000160327
tremorAccAmpCoV 0.0385031
tremorPcRelVar 0.627313
tremorPcX 0.566323
tremorPcY 0.824184

Circle Segment 1

Duration 18.2 s, Accuracy Estimate 2.044 (lower is better)

Circle Segment 2

Duration 10.92 s, Accuracy Estimate 1.404 (lower is better)

Circle Segment 3

Duration 12.6 s, Accuracy Estimate 1.157 (lower is better)

Circle Segment 4

Duration 9.96 s, Accuracy Estimate 1.102 (lower is better)

Circle Segment 5

Duration 9.68 s, Accuracy Estimate 1.773 (lower is better)

Circle Segment 6

Duration 10.28 s, Accuracy Estimate 1.078 (lower is better)

Circle Segment 7

Duration 9.96 s, Accuracy Estimate 1.834 (lower is better)

Circle Segment 8

Duration 11.56 s, Accuracy Estimate 1.624 (lower is better)

Circle Segment 9

Duration 12.16 s, Accuracy Estimate 1.971 (lower is better)

Circle Segment 10

Duration 10.56 s, Accuracy Estimate 3.01 (lower is better)

Spiral

numSpirals 7
timePerSpiralMean 38.3029
timePerSpiralCoV 0.140016
timePerSpiralSlope 0.0119723
meanError 2.14288
tremorFreq 5.85938
tremorRelPower 24.1638
tremorGyroAmpMean 0.0198831
tremorGyroAmpSlope 0.000517721
tremorGyroAmpCoV 0.465135
tremorCoordAmpMean 0.0696757
tremorCoordAmpSlope -0.00431745
tremorCoordAmpCoV 2.71323
tremorAccAmpMean 0.0487378
tremorAccAmpSlope 0.00017258
tremorAccAmpCoV 0.126335
tremorPcRelVar 0.640365
tremorPcX -0.0519892
tremorPcY 0.998648

Spiral Segment 1

Duration 45.52 s, Accuracy Estimate 2.061 (lower is better)

Spiral Segment 2

Duration 33.84 s, Accuracy Estimate 2.35 (lower is better)

Spiral Segment 3

Duration 32.72 s, Accuracy Estimate 2.148 (lower is better)

Spiral Segment 4

Duration 33.32 s, Accuracy Estimate 2.074 (lower is better)

Spiral Segment 5

Duration 37.16 s, Accuracy Estimate 2.399 (lower is better)

Spiral Segment 6

Duration 44.04 s, Accuracy Estimate 1.872 (lower is better)

Spiral Segment 7

Duration 41.52 s, Accuracy Estimate 2.097 (lower is better)

Elel

eDurationMean 0.584881
eDurationStd 0.243232
eDurationStdnorm 0.415865
eDurationMedian 0.525
eDurationQuartdelta 0.1
eDurationQuartdeltanorm 0.190476
eDurationKurt 13.1886
eDurationTrenddiff -0.065
eDurationTrendratio 0.881818
eWidthMean 5.50457
eWidthStd 1.68085
eWidthStdnorm 0.305355
eWidthMedian 4.914
eWidthQuartdelta 1.638
eWidthQuartdeltanorm 0.333333
eWidthKurt 3.37239
eWidthTrenddiff 0.351
eWidthTrendratio 1.075
eHeightMean 11.8031
eHeightStd 2.13093
eHeightStdnorm 0.180541
eHeightMedian 11.8755
eHeightQuartdelta 2.457
eHeightQuartdeltanorm 0.206897
eHeightKurt 3.53202
eHeightTrenddiff -1.287
eHeightTrendratio 0.892157
eAspectMean 0.465966
eAspectStd 0.104664
eAspectStdnorm 0.224618
eAspectMedian 0.436843
eAspectQuartdelta 0.140341
eAspectQuartdeltanorm 0.321262
eAspectKurt 2.1638
eAspectTrenddiff 0.0525553
eAspectTrendratio 1.12532
eSlantMean 0.0940759
eSlantStd 0.139125
eSlantStdnorm 1.47886
eSlantMedian 0.0991055
eSlantQuartdelta 0.143436
eSlantQuartdeltanorm 1.4473
eSlantKurt 4.70916
eSlantTrenddiff 0.0941439
eRtopMean 0.736147
eRtopStd 0.115754
eRtopStdnorm 0.157243
eRtopMedian 0.756757
eRtopQuartdelta 0.138931
eRtopQuartdeltanorm 0.183587
eRtopKurt 3.68858
eRtopTrenddiff 0.00680272
eRbotMean 0.551065
eRbotStd 0.193634
eRbotStdnorm 0.351381
eRbotMedian 0.54381
eRbotQuartdelta 0.252381
eRbotQuartdeltanorm 0.464098
eRbotKurt 3.28737
eRbotTrenddiff -0.137124
eRrightMean 0.844019
eRrightStd 0.0939868
eRrightStdnorm 0.111356
eRrightMedian 0.86991
eRrightQuartdelta 0.120891
eRrightQuartdeltanorm 0.138969
eRrightKurt 5.0235
eRrightTrenddiff -0.0516796
eRleftMean 0.335398
eRleftStd 0.152592
eRleftStdnorm 0.454958
eRleftMedian 0.312814
eRleftQuartdelta 0.214936
eRleftQuartdeltanorm 0.687106
eRleftKurt 4.32043
eRleftTrenddiff -0.127174
lDurationMean 0.747195
lDurationStd 0.272404
lDurationStdnorm 0.364568
lDurationMedian 0.655
lDurationQuartdelta 0.1725
lDurationQuartdeltanorm 0.263359
lDurationKurt 9.24883
lDurationTrenddiff -0.065
lDurationTrendratio 0.904762
lWidthMean 7.14271
lWidthStd 1.43628
lWidthStdnorm 0.201083
lWidthMedian 6.903
lWidthQuartdelta 1.72575
lWidthQuartdeltanorm 0.25
lWidthKurt 3.03654
lWidthTrenddiff -1.287
lWidthTrendratio 0.833333
lHeightMean 23.8024
lHeightStd 3.39976
lHeightStdnorm 0.142833
lHeightMedian 23.985
lHeightQuartdelta 4.47525
lHeightQuartdeltanorm 0.186585
lHeightKurt 3.11318
lHeightTrenddiff -2.808
lHeightTrendratio 0.889908
lAspectMean 0.301808
lAspectStd 0.0524467
lAspectStdnorm 0.173775
lAspectMedian 0.307359
lAspectQuartdelta 0.0758897
lAspectQuartdeltanorm 0.246909
lAspectKurt 2.39742
lAspectTrenddiff -0.0209983
lAspectTrendratio 0.931916
lSlantMean 0.130815
lSlantStd 0.0659189
lSlantStdnorm 0.50391
lSlantMedian 0.139535
lSlantQuartdelta 0.0804549
lSlantQuartdeltanorm 0.576594
lSlantKurt 2.75715
lSlantTrenddiff 0.00528643
lRtopMean 0.847983
lRtopStd 0.0687964
lRtopStdnorm 0.0811295
lRtopMedian 0.861538
lRtopQuartdelta 0.0880825
lRtopQuartdeltanorm 0.102239
lRtopKurt 2.72925
lRtopTrenddiff 0.000832501
lRbotMean 0.430123
lRbotStd 0.144737
lRbotStdnorm 0.336501
lRbotMedian 0.4
lRbotQuartdelta 0.187955
lRbotQuartdeltanorm 0.469886
lRbotKurt 3.69827
lRbotTrenddiff -0.019964
lRrightMean 0.905695
lRrightStd 0.049068
lRrightStdnorm 0.0541771
lRrightMedian 0.917073
lRrightQuartdelta 0.0601209
lRrightQuartdeltanorm 0.0655573
lRrightKurt 4.47664
lRrightTrenddiff 0.00909203
lRleftMean 0.219748
lRleftStd 0.1076
lRleftStdnorm 0.489652
lRleftMedian 0.18932
lRleftQuartdelta 0.108267
lRleftQuartdeltanorm 0.571871
lRleftKurt 3.51368
lRleftTrenddiff -0.0276873

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

Elel Segment 10

FITTS Short Modified

meanTouchScore 0.876843
sumTouchScores 17.5369
meanMovementTime 0.848158
numTouches 20
undershootPercentage 0
overshootPercentage 5

FITTS Long Modified

meanTouchScore 0.879234
sumTouchScores 14.0677
meanMovementTime 1.10833
numTouches 16
undershootPercentage 0
overshootPercentage 6.25

ZigZag

numZigzags 5
timePerZigzagMean 39.848
timePerZigzagCoV 0.155024
timePerZigzagSlope -0.09737
meanError 1.83485
tremorFreq 6.34766
tremorRelPower 25.8222
tremorGyroAmpMean 0.0200569
tremorGyroAmpSlope -0.00049811
tremorGyroAmpCoV 0.430991
tremorCoordAmpMean 0.0413334
tremorCoordAmpSlope -0.000183167
tremorCoordAmpCoV 0.471478
tremorAccAmpMean 0.0499981
tremorAccAmpSlope -0.000136391
tremorAccAmpCoV 0.160002
tremorPcRelVar 0.683688
tremorPcX -0.100332
tremorPcY 0.994954

ZigZag Segment 1

Duration 47.84 s, Accuracy Estimate 1.798 (lower is better)

ZigZag Segment 2

Duration 44.24 s, Accuracy Estimate 1.635 (lower is better)

ZigZag Segment 3

Duration 38.88 s, Accuracy Estimate 1.977 (lower is better)

ZigZag Segment 4

Duration 35.44 s, Accuracy Estimate 1.845 (lower is better)

ZigZag Segment 5

Duration 32.84 s, Accuracy Estimate 1.919 (lower is better)

ZigZag Offset

numZigzags 5
timePerZigzagMean 14.424
timePerZigzagCoV 0.234078
timePerZigzagSlope -0.126456
zigzagHeightMean 57.536
zigzagHeightCoV 0.157828
zigzagHeightSlope -0.0310123
meanError 0.032643
tremorFreq 5.95703
tremorRelPower 26.9912
tremorGyroAmpMean 0.0361424
tremorGyroAmpSlope 0.0020887
tremorGyroAmpCoV 0.284459
tremorCoordAmpMean 0.0983845
tremorCoordAmpSlope -0.0106243
tremorCoordAmpCoV 0.772733
tremorAccAmpMean 0.0509343
tremorAccAmpSlope 0.00343316
tremorAccAmpCoV 0.303027
tremorPcRelVar 0.767163
tremorPcX -0.256454
tremorPcY 0.966556

ZigZag Offset Segment 1

Duration 19.24 s, Accuracy Estimate 0.029 (lower is better)

ZigZag Offset Segment 2

Duration 13.76 s, Accuracy Estimate 0.028 (lower is better)

ZigZag Offset Segment 3

Duration 16.32 s, Accuracy Estimate 0.027 (lower is better)

ZigZag Offset Segment 4

Duration 11.6 s, Accuracy Estimate 0.034 (lower is better)

ZigZag Offset Segment 5

Duration 11.2 s, Accuracy Estimate 0.045 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘PD’, ‘HiSpec_score’: 0.35}
RanFor {‘RanFor_class’: ‘PD’, ‘RanFor_score’: 0.68}
BM_May22 {‘BM_May22_class’: ‘PD’, ‘BM_May22_score’: 0.24378827227561106}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.8806993766494347}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘PD’, ‘BM_PD_Sep22_score’: 0.7137867214078727}